A research on narcolepsy

The reasoning behind this action is because modafinil is an inducer of the CYP3A4 enzymes.

A research on narcolepsy

A person with narcolepsy is likely to become drowsy or fall asleep, often at inappropriate times and places, or just be very tired throughout the day. Narcoleptics are not able to experience the amount of restorative deep sleep that healthy people experience — they are not "over-sleeping".

In fact, narcoleptics live their entire lives in a constant state of extreme sleep deprivation. Daytime naps may occur with little warning and may be physically irresistible. These naps can occur several times a day.

A research on narcolepsy are typically refreshing, but only for a few hours or less. Vivid dreams may be experienced on a regular basis, even during very brief naps. Drowsiness may persist for prolonged periods or remain constant.

In addition, night-time sleep may be fragmented, with frequent awakenings. A second prominent symptom of narcolepsy is abnormal REM sleep. Narcoleptics are unique in that they enter into the REM phase of sleep in the beginnings of sleep, even when sleeping during the day.

Cataplexy is an episodic loss of muscle function, ranging from slight weakness such as limpness at the neck or knees, sagging facial muscles, weakness at the knees often referred to as "knee buckling", [9] or inability to speak clearly, to a complete body collapse.

Episodes may be triggered by sudden emotional reactions such as laughterangersurprise, or fearand may last from a few seconds to several minutes. The person remains conscious throughout the episode.

In some cases, cataplexy may resemble epileptic seizures. Cataplexy also has a severe emotional impact on narcoleptics, as it can cause extreme anxiety, fear, and avoidance of people or situations that might elicit an attack. The opposite of this situation failure to activate this protective paralysis occurs in rapid eye movement behavior disorder.

Periods of wakefulness at night [5] Sleep paralysis is the temporary inability to talk or move when waking or less often, when falling asleep.

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It may last a few seconds to minutes. This is often frightening but is not dangerous. Hypnagogic hallucinations are vivid, often frightening, dreamlike experiences that occur while dozing or falling asleep.

Hypnopompic hallucinations refer to the same sensations while awakening from sleep. These hallucinations may manifest in the form of visual or auditory sensations.

It is estimated that up to 40 percent of people with narcolepsy experience automatic behavior during sleep episodes. In most cases, the first symptom of narcolepsy to appear is excessive and overwhelming daytime sleepiness.

The other symptoms may begin alone or in combination months or years after the onset of the daytime naps. There are wide variations in the development, severity, and order of appearance of cataplexy, sleep paralysis, and hypnagogic hallucinations in individuals.

Only about 20 to 25 percent of people with narcolepsy experience all four symptoms. The excessive daytime sleepiness generally persists throughout life, but sleep paralysis and hypnagogic hallucinations may not. A rare subset of narcoleptics also experience a heightened sense of taste and smell known as the supertaster phenomenon.

A research on narcolepsy

The excessive daytime sleepiness and cataplexy often become severe enough to cause serious problems in a person's social, personal, and professional life.

Normally, when an individual is awake, brain waves show a regular rhythm. When a person first falls asleep, the brain waves become slower and less regular, which is called non-rapid eye movement NREM sleep.

After about an hour and a half of NREM sleep, the brain waves begin to show a more active pattern again, called REM sleep rapid eye movement sleepwhen most remembered dreaming occurs.Jul 06,  · Narcolepsy is a chronic neurological disorder that affects the brain’s ability to control sleep-wake cycles.

People with narcolepsy usually feel rested after waking, but then feel very sleepy throughout much of the day. Many individuals with narcolepsy also experience uneven and interrupted. Medications are a core therapy for most people with narcolepsy, and with optimal treatment, most of them experience large improvements in their alertness.

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Modafinil, sold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea (OSA).

In OSA continuous positive airway pressure is the preferred treatment. While it has seen off-label use as a purported cognitive enhancer, the research on its effectiveness for this use is not conclusive. Sessions/Tracks. Track 1: Sleep Disorder A sleep disorder is a medical disorder of the sleep patterns of a person.

Some sleep disorders are serious enough to interfere with normal physical, mental, emotional and social functioning. Great strides have been made in recent years in understanding the cause(s) of narcolepsy, but much work remains to be done. Your participation in research studies will help researchers to unravel the mysteries that remain.

Narcolepsy Research. Narcolepsy is a serious neurological sleep disorder affecting 1 in 2, people – including , Americans and 3 million people worldwide. Wake Up Narcolepsy is dedicated to accelerating the pace of basic research to better understand the causes of the disease, and develop improved treatment and a cure.

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